The present study was conducted to test antimicrobial, in-vivo brine shrimp lethality and hemolytic assays of the\r\nhexane, ethyl acetate, chloroform, methanol and ethanolic extracts of Kalinga ornata. The antimicrobial effect of different extract\r\nof Kalinga ornata determined against ten pathogenic bacteria and fungi. All the extracts showed minimum zone of inhibition\r\nagainst Escherichia coli, Klebsiella pneumonia, Proteus mirabilis, Pseusdomonas aeruginosa, Salmonella typhi, Salmonella\r\nparatyphi, Staphyloccus aureus, Aspergillus flavus, A. niger, Candida albicans and Pencillium Sp. According to brine shrimp\r\nlethality test ten nauplii were added into three replicates of each concentration of the Kalinga ornata extract. After 24 hours the\r\nsurviving brine shrimp larvae were counted and LC50 was assessed. Results showed that the extract of Kalinga ornata was\r\npotent against the brine shrimp with LC50 values of 40, 80 and 100 ppm (?g/ml), respectively. The hemolytic activity was also\r\nestimated as 128 HU/mg chicken blood erythrocytes. This study indicated that bioactive components are present in the Kalinga\r\nornata and the results support new marine source for drug development.
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